In all domains of life, transmembrane proteins from the ATP‐binding cassette (ABC) transporter family drive the translocation of diverse substances across lipid bilayers. In pathogenic fungi, the ABC transporters of the pleiotropic drug resistance (PDR) subfamily confer antibiotic resistance and so are of interest as therapeutic targets. They also drive the quest for understanding how ABC transporters can generally accommodate such a wide range of substrates. The Pdr5 transporter from baker's yeast is representative of the PDR group and, ever since (...) its discovery more than 30 years ago, has been the subject of extensive functional analyses. A new perspective of these studies has been recently provided in the framework of the first electron cryo‐microscopy structures of Pdr5, as well as emergent applications of machine learning in the field. Taken together, the old and the new developments have been used to propose a mechanism for the transport process in PDR proteins. This mechanism involves a “flippase” step that moves the substrates from one leaflet of the bilayer to the other, as a central element of cellular efflux. (shrink)

Previous studies have shown that children retreat from argument‐structure overgeneralization errors (e.g., *Don’t giggle me) by inferring that frequently encountered verbs are unlikely to be grammatical in unattested constructions, and by making use of syntax‐semantics correspondences (e.g., verbs denoting internally caused actions such as giggling cannot normally be used causatively). The present study tested a new account based on a unitary learning mechanism that combines both of these processes. Seventy‐two participants (ages 5–6, 9–10, and adults) rated overgeneralization errors with higher (...) (*The funny man’s joke giggled Bart) and lower (*The funny man giggled Bart) degrees of direct external causation. The errors with more‐direct causation were rated as less unacceptable than those with less‐direct causation. This finding is consistent with the new account, under which children acquire—in an incremental and probabilistic fashion—the meaning of particular constructions (e.g., transitive causative = direct external causation) and particular verbs, rejecting generalizations where the incompatibility between the two is too great. (shrink)

This paper proposes several concepts of efficient solutions for multicriteria decision problems under uncertainty. We show how alternative notions of efficiency may be grounded on different decision ‘contexts’, depending on what is known about the Decision Maker's (DM) preference structure and probabilistic anticipations. We define efficient sets arising naturally from polar decision contexts. We investigate these sets from the points of view of their relative inclusions and point out some particular subsets which may be especially relevant to some decision situations.

In this paper two models for movement of respiratory gases in the insect trachea are presented. One model considers the tracheal system as a single flexible compartment while the other model considers the trachea as a single flexible compartment with gas exchange. This work represents an extension of Ben-Tal’s work on compartmental gas exchange in human lungs and is applied to the insect tracheal system. The purpose of the work is to study nonlinear phenomena seen in the insect respiratory system. (...) It is assumed that the flow inside the trachea is laminar, and that the air inside the chamber behaves as an ideal gas. Further, with the isothermal assumption, the expressions for the tracheal partial pressures of oxygen and carbon dioxide, rate of volume change, and the rates of change of oxygen concentration and carbon dioxide concentration are derived. The effects of some flow parameters such as diffusion capacities, reaction rates and air concentrations on net flow are studied. Numerical simulations of the tracheal flow characteristics are performed. The models developed provide a mathematical framework to further investigate gas exchange in insects. (shrink)

This Festschrift for Professor Baron's sixtieth birthday displays an astonishing variety of interests on the part of his former students, from the sociological study of the American conservative Rabbinate to the correspondence of Tobias ben Moses and the New York cloakmakers' strike of 1910. Essays of philosophic interest are Bokser's "Morality and Religion in the Theology of Maimonides," Hahn's "Wellhausen's Interpretation of Israel's Religious History," Blau's "Tradition and Innovation," and Ben-Horin's "Toward the Dawn of History". The volume includes an extensive (...) bibliography of Baron's writings. --L. S. F. (shrink)

All accounts of language acquisition agree that, by around age 4, children’s knowledge of grammatical constructions is abstract, rather than tied solely to individual lexical items. The aim of the present research was to investigate, focusing on the passive, whether children’s and adults’ performance is additionally semantically constrained, varying according to the distance between the semantics of the verb and those of the construction. In a forced‐choice pointing study (Experiment 1), both 4‐ to 6‐year olds (N = 60) and adults (...) (N = 60) showed support for the prediction of this semantic construction prototype account of an interaction such that the observed disadvantage for passives as compared to actives (i.e., fewer correct points/longer reaction time) was greater for experiencer‐theme verbs than for agent‐patient and theme‐experiencer verbs (e.g., Bob was seen/hit/frightened by Wendy). Similarly, in a production/priming study (Experiment 2), both 4‐ to 6‐year olds (N = 60) and adults (N = 60) produced fewer passives for experiencer‐theme verbs than for agent‐patient/theme‐experiencer verbs. We conclude that these findings are difficult to explain under accounts based on the notion of A(rgument) movement or of a monostratal, semantics‐free, level of syntax, and instead necessitate some form of semantic construction prototype account. (shrink)

This study addresses the conceptual affinities between F. W. J. Schelling and Félix RavaissonRavaisson-Mollien, Félix by focusing on the genesis of the link between nature and thought in their respective philosophies. To achieve this, it considers the role of diagrammatic representation in depicting this link—particularly in the figure of the spiral. I argue that, for Schelling, the spiral is a real pattern that suggests the polarity of the mental and the physical whereas, for RavaissonRavaisson-Mollien, Félix, it is a memory of (...) the condition of action and a condition of grace. I cash out this argument by considering not only Schelling’s philosophy of nature, where the spiral is manifest in the vortex of the First Outline of the System of the Philosophy of Nature, and RavaissonRavaisson-Mollien, Félix’s OfHabitHabit, but also RavaissonRavaisson-Mollien, Félix’s essays on fine art, Leonardo da Vinci and the serpentine line. (shrink)

In the present essay I address the apparently problematic status of epistemology in F.W.J. Schelling’s work. Given the overblown emphasis on Schelling’s anti-Kantianism, there would seem to be little hope in articulating anything like a theory of knowledge in Schelling’s thought. For the sake of brevity I emphasize knowledge’s spatial and navigational functions in Schelling’s texts. For Schelling, the navigational is that which locates, and constructively constrains, the capacity of the subject to synthesize. This is accomplished, I argue, via a (...) spatialized reading of Schelling’s concept of intellectual intuition. While this form of intuition initially resembles that of Fichte’s, Schelling transforms the term, using it in tandem with construction, in order to maintain both the sensory immediacy, yet abstract form, of intuition as the initial means a knowing subject, immersed in the activities of nature, comes to recognize its own capacities and begins to form claims about the world. (shrink)

This essay reconsiders the haphazard arrangement of Donne's first printed collection of poems in relation to an elegy written for Donne by one Thomas Browne, published for the first and only time in that same volume. The earliest recorded response we have to Donne's verse considered as a complete body of work, Browne's elegy thematizes the readerly tendency to interpret this textual body in the light of "subjective" notions of "proper" desire. Through a close reading of Browne's poem, in which (...) I contextualize his key image of the bad reader as a "circumciser" within the theological and medical discourses of the period, I argue that Browne's response to Donne's text is at once instructively prescient -- providing a useful allegory of reading for the contemporary critic -- and also helpful in situating Donne at the cusp of a historical transformation between "medieval" and "early modern" conceptions of the sexual and the spiritual.IThe structural organization of John Donne's first printed book of poetry makes no obvious sense. Published posthumously in 1633, the collection eschews even the basic generic distinctions so familiar to Donne's modern audience: "Songs and Sonnets," "Satires," "Verse Letters," and "Divine Poems" . Several readers over the years have commented upon the disorderly configuration of Donne's 1633 text; and most recently, Leah Marcus has provided a detailed analysis of the collection in Unediting The Renaissance, itself an ambitious attempt to combine the traditional skills of textual bibliography with the insights of poststructuralist theory. Among other things, Marcus asserts that the very layout and internal composition of Donne's first collection constitute graphic evidence for the ultimate impossibility of "fixing" him within any reductively binary scheme. Indeed, for Marcus, the version of Donne projected by the 1633 Poems confirms not only her deconstructivist principles but also her aesthetic taste more generally. In her words, the collection is a striking melange of sacred and secular that refuses to separate John Donne from Jack. Verse epistles . . . jostle up against scurrilous amatory verses and evocations of human decay in a rough gallimaufry of mingled passions that projects a John Donne very like the Donne most of us value, a Donne for whom the sacred and secular are so closely entwined as to be inseparable.This reading would probably not be considered controversial in most quarters, and I too am in agreement with the main points of Marcus's argument, insofar as they go. However, I want to pause for a moment over one of the more undeveloped aspects of Marcus's interpretation, encoded in her use of the phrase "most of us." As the context makes clear, by "most of us" Marcus means a rather small band of nonreligious or liberal, professionalized, twentieth-century readers. Of course, Marcus is perfectly justified in assuming that her audience will be drawn from exactly this narrow demographic , but at the same time it must also be admitted that "most of us" therefore only refers to the tiniest portion of Donne's actual historical readership. Given that Marcus is performing an analysis of Donne's 1633 Poems, then, one obvious question emerges from her account: How might readers in 1633 have responded to the collection's juxtaposition of the religious with the secular? What might its disorganization have signified for them?One possible answer to this question has been suggested by Arthur F. Marotti, perhaps the most influential of Donne's textualist critics. In Manuscript, Print, and the English Renaissance Lyric, Marotti suggests, against Marcus, that Donne's first editors deliberately delay the readerly encounter with Donne's more earthly lyrics by burying them toward the back of the book. In other words, according to Marotti, the appearance of random disorganization that Marcus values is actually an intentional blind -- the result of a conscious attempt to "protect the reputation of Dean Donne from moral taint."However, this ingenious theory is not without flaws. For example, we are required to accept Marotti's contention. (shrink)

The philosophical works of F. Rosenzweig have particular meaning for both academic and existential inquiries and interests, as he deeply re-observes the religious life of Judaism and Christianity through the reflection of human existence. Fear of death, observation of Plato’s understanding of Eros, overcoming of atheism of Goethe in the experience of faith - these key motives form a challenging discourse of Rosenzweig’s theological and philosophical thought, which invites reader into a truly charming spiritual journey. The article provides an intriguing (...) introduction to the issue of RUDN Journal of Philosophy, which is dedicated to F. Rosenzweig and provides a scope to various aspects of the philosophy of one of the most prominent German-Jewish thinkers of the twentieth century, including topics such as criticism and reception of German idealism and existentialism, «new thinking» as a philosophical system, philosophical interpretation of biblical texts, Kabbalah and mysticism. (shrink)

If ${\mathfrak {F}}$ is a type-definable family of commensurable subsets, subgroups or subvector spaces in a metric structure, then there is an invariant subset, subgroup or subvector space commensurable with ${\mathfrak {F}}$. This in particular applies to type-definable or hyper-definable objects in a classical first-order structure.

In this review I argue that while Berger makes out a good argument that the language of civic engagement covers too much (and hence too little) and that education plays a vital role in developing civic-minded sensibilities, I am less sanguine that the strategies for the reform of our “attention deficit democracy” will achieve the desired effect in a political society dominated by the corrupting influence of corporations who actively seek to undermine just such sensibilities as anathema to their objectives. (...) As corporate objectives become more and more wedded to the state, so too reform becomes less and less likely to be successful. An excellent example of this is the power wielded by the current incarnation of the fossil fuel empire and it’s influence over law-making concerning hydraulic fracturing in Pennsylvania. While I applaud Berger’s objectives, I am no longer convinced that pragmatism and not a more revolutionary approach can fulfill Berger’s—and my own—democratic ideals. (shrink)

In this review I argue that while Berger makes out a good argument that the language of civic engagement covers too much (and hence too little) and that education plays a vital role in developing civic-minded sensibilities, I am less sanguine that the strategies for the reform of our “attention deficit democracy” will achieve the desired effect in a political society dominated by the corrupting influence of corporations who actively seek to undermine just such sensibilities as anathema to their objectives. (...) As corporate objectives become more and more wedded to the state, so too reform becomes less and less likely to be successful. An excellent example of this is the power wielded by the current incarnation of the fossil fuel empire and it’s influence over law-making concerning hydraulic fracturing in Pennsylvania. While I applaud Berger’s objectives, I am no longer convinced that pragmatism and not a more revolutionary approach can fulfill Berger’s—and my own—democratic ideals. (shrink)

This chapter contains sections titled: Socrates Café Café Philosophique Philosophy for Everyone Sophistry The Examined Life Oblivion Conclusion (Who is Ben's Mom?).

The language of standard propositional modal logic has one operator (? or ?), that can be thought of as being determined by the quantifiers ? or ?, respectively: for example, a formula of the form ?F is true at a point s just in case all the immediate successors of s verify F.This paper uses a propositional modal language with one operator determined by a generalized quantifier to discuss a simple connection between standard invariance conditions on modal formulas and generalized (...) quantifiers: the combined generalized quantifier conditions of conservativity and extension correspond to the modal condition of invariance under generated submodels, and the modal condition of invariance under bisimulations corresponds to the generalized quantifier being a Boolean combination of ? and ? (shrink)

The volume includes the proceedings from the conference FOL75 -- 75 Years of First-Order Logic held at Humboldt University, Berlin, September 18 - 21, 2003 on the occasion of the anniversary of the publication of Hilbert's and Ackermann's Grundzuge der theoretischen Logik. The papers provide analyses of the historical conditions of the shaping of FOL, discuss several modern rivals to it, and show the importance of FOL for interdisciplinary research. While there is no doubt that the celebrated book marks a (...) most important step in the development of logic, the volume in hand proves the actuality of the question "Which logic is the right logic." The volume contains articles by: H. Andreka, J. X. Madarasz, I. Nemeti, A. Avron, K. Brunnler, A. Guglielmi, G. Englebretsen, W. Ewald, P. Hajek, J. Hintikka, W. Hodges, M. Kracht, R. Lanzet, H. Ben-Yami, C. Toke, S. P. Odintsov, H. Wansing, J. A. Robinson, M. Rossberg, M. Thielscher, D. E. Willard, andJ. Wole 'nski. (shrink)

An updated and extended second edition supporting the findings of its well-known predecessor which claimed that courts employ common-sense notions of causation in determining legal responsibility.

Collected and edited by Noah Levin -/- Table of Contents: -/- UNIT ONE: INTRODUCTION TO CONTEMPORARY ETHICS: TECHNOLOGY, AFFIRMATIVE ACTION, AND IMMIGRATION 1 The “Trolley Problem” and Self-Driving Cars: Your Car’s Moral Settings (Noah Levin) 2 What is Ethics and What Makes Something a Problem for Morality? (David Svolba) 3 Letter from the Birmingham City Jail (Martin Luther King, Jr) 4 A Defense of Affirmative Action (Noah Levin) 5 The Moral Issues of Immigration (B.M. Wooldridge) 6 The Ethics of our (...) Digital Selves (Noah Levin) -/- UNIT TWO: TORTURE, DEATH, AND THE “GREATER GOOD” 7 The Ethics of Torture (Martine Berenpas) 8 What Moral Obligations do we have (or not have) to Impoverished Peoples? (B.M. Wooldridge) 9 Euthanasia, or Mercy Killing (Nathan Nobis) 10 An Argument Against Capital Punishment (Noah Levin) 11 Common Arguments about Abortion (Nathan Nobis & Kristina Grob) 12 Better (Philosophical) Arguments about Abortion (Nathan Nobis & Kristina Grob) -/- UNIT THREE: PERSONS, AUTONOMY, THE ENVIRONMENT, AND RIGHTS 13 Animal Rights (Eduardo Salazar) 14 John Rawls and the “Veil of Ignorance” (Ben Davies) 15 Environmental Ethics: Climate Change (Jonathan Spelman) 16 Rape, Date Rape, and the “Affirmative Consent” Law in California (Noah Levin) 17 The Ethics of Pornography: Deliberating on a Modern Harm (Eduardo Salazar) 18 The Social Contract (Thomas Hobbes) -/- UNIT FOUR: HAPPINESS 19 Is Pleasure all that Matters? Thoughts on the “Experience Machine” (Prabhpal Singh) 20 Utilitarianism (J.S. Mill) 21 Utilitarianism: Pros and Cons (B.M. Wooldridge) 22 Existentialism, Genetic Engineering, and the Meaning of Life: The Fifths (Noah Levin) 23 The Solitude of the Self (Elizabeth Cady Stanton) 24 Game Theory, the Nash Equilibrium, and the Prisoner’s Dilemma (Douglas E. Hill) -/- UNIT FIVE: RELIGION, LAW, AND ABSOLUTE MORALITY 25 The Myth of Gyges and The Crito (Plato) 26 God, Morality, and Religion (Kristin Seemuth Whaley) 27 The Categorical Imperative (Immanuel Kant) 28 The Virtues (Aristotle) 29 Beyond Good and Evil (Friedrich Nietzsche) 30 Other Moral Theories: Subjectivism, Relativism, Emotivism, Intuitionism, etc. (Jan F. Jacko). (shrink)

Ἀσέβεια is one of Greek religion's vexatious topics. It was a crime, or γραφή, as well as a religious wrong according to ‘sacred law’. It happened to be the charge in the most famous Greek trial, that of Socrates, and thus became part of alocus classicus, with the result, as Kenneth Dover showed, that later reports of ἀσέβεια trials were often distorted by the influence of Socrates' example. Focussing mostly on the sources found reliable by Dover, this article proposes that (...) ἀσέβεια sometimes resembled μίασμα, which was contagious religious pollution. An impious person could sometimes spread his or her ἀσέβεια, and others could catch it. (shrink)